native glp 1 Oral GLP-1-Based Therapeutics in the Obesity–Metabolic Syndrome–Diabetes Continuum: Translational Advances, Clinical Barriers, and Emerging Strategies Frontiers | The central GLP-1:

BPC-157 BPC-157 is a synthetic pentadecapeptide

J., Hammerman, M

The CNS GLP- 1 receptors are not necessary for the physiological regulation of blood glucose levels by endogenous GLP- 1 or the pharmacological control of glucose homeostasis that depends on GLP- 1 receptors, although further research is needed to investigate the possible role of GLP- 1 receptors expressed outside the beta cell, including within the enteric and peripheral nervous systems, in improving beta cell function through enteral glucose mediation [70, 84]

Tirzepatide: Stands out for its dual agonism (GLP-1 and GIP receptors), resulting in substantial weight loss in addition to glycemic control