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As depicted in Figure 3, we propose that the lactate-lactylation axis drives PH pathogenesis through five key mechanisms: PASMC proliferation, immune-inflammatory responses, pulmonary fibrosis, abnormal vasoconstriction, and PASMC ferroptosis

Overexpression of Glucose-6-phosphate Dehydrogenase Extends the Life Span of Drosophila melanogaster

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PMID: 32001676