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Funding This work was supported by the Department of Science and Technology, Government of India under the scheme of Women Scientist [WOS-B /DST/WOS-B/HN-25/2021-RENU (G)]

Well, again, it all depends on the significance of the disease or what the patient isthats another, I like to say, loaded question

Administration of 300 mg/kg of APAP led to 100% mortality within 6 h, but 1,000 mg/kg of natsumikan extract and silymarin prolonged survival rates to 33.3% and 50.0%, respectively

Cycling protocols are designed to reduce this risk, but the concern highlights why continuous unsupervised use is not recommended