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GLP-1 agonists for type 2 diabetes, Trulicity and Victoza, are funded for diabetes patients who qualify, though supplies have been vulnerable to global shortages

Persistent synovitis can induce VEGF production, promoting neovascularization and increased vascular permeability (143), which may facilitate the influx of iron into the joint cavity and subchondral bone and recruit additional immune cells, thereby intensifying local oxidative stress and inflammatory cascades (144)

The Khavinson primate studies are most relevant here: Epitalon increased nighttime melatonin in old monkeys while having no effect on young ones

Selenium deficiency and dysregulation of selenoproteins are associated with impairments to redox homeostasis in cartilage