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The STEP-1 body-composition substudy (n=140 DXA cohort) of semaglutide (Wegovy at 2.4 mg weekly) reported fat-free mass loss of approximately 6.9 kg over 68 weeks, accounting for approximately 45% of total weight loss based on the body-composition substudys own arithmetic and the Conte 2024 systematic review [6, 7]

Some women can experience nausea, nausea, and/or loose stools when starting, but they usually settle with gradual dose escalation

However, the trial is listed as canceled, which indicates the study sponsor or investigator recalled a submission of study results before quality control review took place