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In addition, numerous metabolites and cells from microorganisms can regulate the immune microenvironment and act as antioxidants

First and foremost, the evidence for the anti-fibrotic efficacy of these specific natural products is almost exclusively derived from preclinical ( in vivo animal and in vitro cellular) models

264 The role of ERAD and UPR in cancer The UPR as a stress-adaptive survival network in tumor cells The UPR is frequently upregulated in cancer, reflecting its central role in enabling tumor cells to cope with sustained proteotoxic stress

Methods Animals Neonatal (P2-P4) Sprague-Dawley rats were used for the experiments described here