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Atherosclerosis creates a cycle where excess ROS and inflammatory proteins mutate genes, disrupt energy and hormone balance, and activate WBCs and platelets

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Recent work using single nuclear RNA sequencing and translating ribosome affinity purification sequencing showed that mHtt mediates the release of mitochondrial RNA which then binds to the innate immune sensor protein kinase R, resulting in the activation of innate immune signaling in the most vulnerable HD neurons: spiny projection neurons (Lee et al., 2020)