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Most common GLP-1 side effects The most common side effects of Semaglutide (GLP-1) medications include nausea, diarrhea, vomiting, constipation, abdominal (stomach) pain, headache, fatigue, dyspepsia (indigestion), dizziness, abdominal distension, eructation (belching), hypoglycemia (low blood sugar) in patients with type 2 diabetes, flatulence (gas buildup), gastroenteritis (an intestinal infection), and gastroesophageal reflux disease (a type of digestive disorder)

Effects in PCOS GLP-1 RAs have been extensively studied in women with PCOS due to overlapping metabolic abnormalities

Activation of these receptors reduces oxidative stress, lowers inflammatory cytokines, and enhances mitochondrial performance

Oral semaglutide (Rybelsus) shows that large peptides can be taken without injections by using advanced drug formulations, but skin patches cannot deliver them