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Although the FDA has issued a boxed warning for semaglutide, based on animal studies indicating a risk for thyroid C-cell tumors [48], no target-organ toxicity emerged, and there was no signal for thyroid C-cell hyperplasia, an observation later corroborated in clinical trials

As the success of a computational pipeline heavily depends on the data, the selection of the appropriate dataset(s) relevant to the biological question and the necessary analyses is a crucial first step

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The increase was modest and did not produce clinical events in the trial population, but researchers with pre-existing cardiovascular conditions should factor this into their risk assessment