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For example, the variant 677T is most commonly associated with cerebral vascular accident (stroke), elevated homocysteine, cardiovascular disease risk, peripheral neuropathy, deep vein thrombosis, early-onset heart disease, stillbirth, neuro-tube defect, cleft lip, and preeclampsia

Time-lapse recordings spanning the whole cells (z-step: 1 m, stack of about 15 confocal images with a size of 1024 1024 pixels) were taken at 1 min intervals (XYZT imaging)

Numerous studies utilizing adenoviral transduction of FAK-related non-kinase (FRNK), an endogenous dominant-negative inhibitor of the FAK FAT domain, showed displacement of FAK from focal adhesions, leading to increased cell rounding, detachment, and apoptosis 18,19

doi: 10.2174/0115748871308473240926044126 189 TanQZhouHJiaJCuiJSunLZhengWet al