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Brooks D, Barr LC, Wiscombe S, McAuley DF, Simpson AJ, Rostron AJ

270 Interestingly, a study on the correlation between amino acid metabolism and the immune microenvironment in LUAD (Lung adenocarcinoma) patients found that SLC7A5 expression was downregulated in various T cells, especially in effector T cells

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Common gastrointestinal side effects are the most frequently reported adverse reactions, particularly during treatment initiation and dose escalation: Nausea (affecting 2040% of patients initially) Vomiting and diarrhoea Constipation Abdominal discomfort or bloating These symptoms typically diminish over several weeks as tolerance develops