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The strategies used for managing GI symptoms with existing GLP-1 receptor agonists such as semaglutide and tirzepatide are likely to be broadly applicable, though retatrutide-specific guidance will develop as more clinical experience accumulates

Iteratively repeat the amino acid addition and deprotection steps: According to the amino acid sequence, the protected amino acids are sequentially added, and the activation and conjugation reactions are carried out

Semaglutide is not recommended during pregnancy, but the medication itself does not cause infertility

These trials have consistently demonstrated the role of GLP-1 RAs in reducing major adverse cardiovascular events (MACE), non-fatal myocardial infarction, non-fatal stroke, and composite heart failure events