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And in my experience with complex patients, the mast cell, POTS, and chemically sensitive populations who cannot tolerate aggressive pharmaceutical interventions under any circumstances, this gentler approach has made GLP-1 therapy accessible to people who would have been completely excluded from it at standard doses

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That is especially true if the deeper goal is not just a lower weight, but better metabolic health, better energy, lower cardiovascular risk, and better long-term function

Clin Chem 41 : 361366