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Study characteristics The included studies were published between 2016 and 2025, with sample sizes ranging from 3,183 to 17,604 participants

According to Novo Nordisk 's announcement and independent reporting: Clinical Trial Results (OASIS 4): According to the published clinical trial data in the New England Journal of Medicine, oral semaglutide 25 mg taken once daily demonstrated 16.6% mean weight loss when treatment was adhered to in adult participants with obesity or overweight with one or more comorbidities

The pre-post KT paired-samples t-tests in completers indicated significant improvements in EDI-3, CIA, STAI, and TCI Harm Avoidance (Table 2)