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Where it differs structurally as a synthetic peptide is the addition of the amino acid tyrosine at the N-terminus to provide additional stability to the peptide (hence a longer half-life), seen on the top-right corner of the picture below: (Source) Hence why youll also see it labeled as Tyr-hGH Frag 176-191
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To investigate the role of nitric oxide signaling, mice received the nitric oxide synthase inhibitors N-Nitro-L-arginine methyl ester (L-NAME, 1 mg/kg) or aminoguanidine (AG, 200 mg/kg) prior to histamine administration
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