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Systemic Wnt pathway activation through oral or injectable drugs would raise more significant concerns than localized topical application

Research Findings Research on GHK-Cu spans over five decades and encompasses in vitro cell culture studies, animal models of wound healing and aging, human clinical trials in dermatology and wound care, and extensive real-world experience from commercial cosmetic applications

By inhibiting activation of latent TGF-1, the agent SRK-181-mIgG1 can sensitise tumour response to anti-PD-1 treatment in preclinical models, without causing evident toxicities [323, 324]