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Running out mid-titration is not just inconvenient

Leung et al., 2019

The dedicated cardiovascular trial did not find excess major events and reported lower all-cause mortality, but resting heart rate remains a titration marker rather than a one-time measurement. How to Titrate, and the Cost of Going Too Fast The final dose shapes the endpoint, but escalation speed is the largest modifiable driver of side effects

47,31,33,35 The relationship seems to be between pancreatitis and weight loss rather than the GLP-1 receptor agonist