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We certify that government regulations concerning the ethical use of animals were adhered to during this research

Pevonedistat (MLN4924) is a highly potent and selective inhibitor of neddylation (IC50 value of 4.7 nM), which can block neddylation modification

Cellular energy regulation: Studies exploring metabolic signaling and energy expenditure pathways

The PCR product was digested with Sac I and Pst I and then inserted into the sites of pTrc99a digested with the same enzymes to form the plasmid pTrc99a- as