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Following tests in animals, Amylin launched trials of its new synthetic version of exendin-4 in humans

If you are tolerating 8 mg well with consistent weight loss of 1 to 2 pounds per week, staying at 8 mg is entirely reasonable

The insulinotropic and glucagon-suppressing effects of GLP-1 agonists directly address these goals, making them an established component of diabetes treatment algorithms

Eli Lilly announced the topline results in December 2025: in obese participants with knee osteoarthritis, the 12 mg dose delivered a mean weight loss of 28,7% (32,3 kg / 71,2 lbs) at 68 weeks, and the 9 mg dose delivered a 26,4% reduction