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The disease is marked by the onset of excessive inflammation followed by collagen deposition and ultimately causing fibrosis in the lung at about 3 to 6 months post radiotherapy [61, 62]
Leucine promotes cell signaling and muscle protein synthesis and has proven safe and effective in some clinical trials without adverse effects.14 Leucine supplementation in the elderly may even help improve muscle mass by providing anabolic stimuli to muscles
doi: 10.1016/j.anireprosci.2014.07.015 [DOI] [PubMed] [Google Scholar] 7
We adopted a male-only design in this preliminary mechanistic investigation to reduce endocrine-related variability associated with the estrous cycle and estrogen, which can modulate microglial activation and neuroinflammatory responses, thereby facilitating more stable identification of gutbrain inflammatory signaling and glial lipotoxic mechanisms following PBAT-MPs exposure
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