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209 , 449.e1449.e7 (2013)

Johns Wort is a common supplement known to interfere with many birth control methods

Conclusions and future perspectives In recent years a growing body of evidence has demonstrated that the malfunctioning of astrocytes may contribute to various neurodegenerative diseases, including Alzheimer, ALS, multiple sclerosis, and Parkinson

Although astrocyte reactivity is likely in the first instance to be targeted at maintaining CNS homoeostasis and circuit functions, various mechanisms could alter astrocyte functions in potentially detrimental ways, including (i) persistent reactivity may contribute to chronic neurodegenerative disorders or chronic inflammation, (ii) ageing and cellular senescence which may alter and reduce astrocyte functional capacities, or (iii) genetic mutations in diseased astrocytes or polymorphisms may alter normal astrocyte functions or responses