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This phase 3, double-blind, placebo-controlled trial conducted across multiple nations represents the lengthiest investigation into semaglutide's efficacy for weight management

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GLP-1 receptors are distributed throughout the brain, with concentrations in the hypothalamus, brainstem, and areas involved in reward processing

5 These benefits might come from several factors: Weight loss itself improves mood and self-esteem Reduced inflammation (which is linked to depression) Direct effects on GLP-1 receptors in the brain, which are present in areas involved in mood regulation Improved physical function and mobility Healthier eating habits developed while on the medication Evidence suggesting caution is needed However, pharmacovigilance studies (which analyse reports of side effects submitted to drug safety databases) have identified signals for psychiatric adverse events with GLP-1 medications, including semaglutide