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The systemic administration of large molecules can lead to off-target effects and potentially induce adverse reactions in tissues that are not the intended target [14]

In many cases, poorly soluble molecules tend to remain in the digestive tract and be eliminated before being absorbed, but cyclodextrins prevent this process [28]

MNMs overcome the limitations of passive diffusion inherent in traditional drug carriers by leveraging their autonomous motility, enabling them to traverse complex biological barriers, such as the gastrointestinal mucus barrier and tumor stroma

Structural insights into the recognition of histone H3Q5 serotonylation by WDR5