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Other reasons include: bariatric surgery or bowel resection, age, those with GI diseases such as Crohns and Celiac, people taking Metformin to control their blood sugar and thos taking proton pump inhibitors (Prevacid, Prilosec, etc) for chronic heartburn

Scientific interest includes: Biological age reduction Cellular rejuvenation Tissue regeneration Healthspan extension Age-related degeneration research Animal models continue to explore the relationship between senescent cell clearance and healthy aging

The bulk of clinical evidence about BBB breakdown is derived from postmortem human brain tissue analyses, which inherently limits our ability to assess real-time dysfunction or track disease progression [27, 309]

Indication specific labs are ordered when a clinical question requires them, for example IGF-1 before a growth hormone secretagogue, a metabolic panel before a fat loss peptide, or thyroid markers when symptoms suggest it