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Contribution of cytochrome P450 2D6 to 3, 4-methylenedioxymethamphetamine disposition in humans: use of paroxetine as a metabolic inhibitor probe

11.3.3 potential risks and challenges of modulating CUL5 in cellular immunotherapies CUL5 is widely expressed in the human body (139) and participates in numerous physiological functions, including the regulation of cell proliferation and the cell cycle (50), DNA damage response and repair (102, 202), maintenance of proteostasis, and signal transduction (119)