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Appetite suppression is intentional and therapeutic, yet some patients report loss of interest in previously enjoyed foods or subtle changes in taste perception

Counteracting this complex landscape, this necessitated the development of synthetic agonists that provide a robust and persistent stimulus, thereby overcoming the pharmacokinetic limitations of the native hormone

10.1021/acs.jmedchem.0c00781 148 Pinzn-GarcaA

Retatrutide represents a promising area of ongoing research in metabolic medicine, but evidence-based, regulated care with currently approved therapies remains the cornerstone of safe clinical practice