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TB-500 is the synthetic peptide fragment corresponding to the central actin-binding domain of Thymosin Beta-4 and specifically the 17 amino acid region containing the LKKTETQ motif responsible for G-actin sequestration and the downstream biological activities of the full 43 amino acid protein

Preclinical models have examined its effects on gastrointestinal and musculoskeletal tissue

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The introduction of alternateand sometimes biomimeticfunctional groups can either improve potency of lipids as agonists/antagonists or increase flexibility for derivatization