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More recent research suggests that the reduction in IQ scores is more pronounced in girls, indicating potential gender differences (Rahman et al., 2017

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There's also the need for sterile equipment and careful preparation

Agisha et al., Pseudomonas fluorescens to the phyllosphere of an apple scab-susceptible apple ( Malus domestica ) cultivar led to the up-regulation of genes encoding proteins participating in pathogen recognition, signaling and antimicrobial defense such as PR-proteins, thioredoxin-like proteins, heat shock proteins and a GST (Krkcoglu et al., 2007)