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There were 12 serious adverse events recorded across the trial, including one suspected unexpected serious adverse reaction related to restrictive eating behaviour in a participant receiving semaglutide

If either exists, GLP-1 medications are absolutely contraindicated Medications reviewed: Ensure your medication timing plan accounts for levothyroxine separation Supplement review: Identify any supplements that might interact with either medication Starting dose strategy for thyroid patients Both semaglutide and tirzepatide are started at low doses and titrated upward

Physiology The term incretin effect refers to the amplification of insulin secretion instigated by oral glucose ingestion compared to an equivalent amount of glucose delivered intravenously

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