"Anything that is going to produce robust weight loss," Apovian says, "there's going to be a percentage of that that's muscle." Reports suggest that GLP-1 treatments may cause between 25 to 40 percent loss of lean mass, which includes muscle massalthough more studies are needed to understand how this affects strength
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[13] A 2021 meta-analysis found that over 1 year of clinical use, tirzepatide was superior to dulaglutide, semaglutide, insulin degludec, and insulin glargine in improving blood sugar control and reducing body weight