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Fibroblast growth factor 21 (FGF21) inhibits ferroptosis by downregulating HO-1

This controlled copper transport serves as cofactor for critical enzymes including: Lysyl oxidase: Essential for collagen and elastin cross-linking Lysyl hydroxylase: Required for proper collagen synthesis Superoxide dismutase: Provides antioxidant defense mechanisms Cytochrome c oxidase: Powers cellular respiration Tyrosinase: Facilitates melanin production The peptide can readily obtain Cu from plasma albumin, functioning bidirectionally to transport copper into or out of cells based on cellular requirements

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