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In addition, the compound did not trigger the nausea, malaise and gastrointestinal adverse effects commonly seen with many first-generation GLP-1 therapies, a distinction that could become increasingly significant as patient populations and adherence demands grow

Suicidality: under active investigation Regulatory bodies, including the European Medicines Agency, have been reviewing a potential association between GLP-1 drugs and suicidal ideation

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There are several reasons behind this recommendation