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Beyond weight, the SELECT trial (N=17,604) published in the New England Journal of Medicine in 2023 showed that semaglutide 2.4 mg reduced major adverse cardiovascular events (MACE) by 20% compared to placebo in adults with overweight or obesity and established cardiovascular disease, over a median follow-up of 39.8 months (HR 0.80 to 95% CI 0.72 to 0.90)

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