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Link: Reuters report on Lillys May 21, 2026 retatrutide obesity trial update: Retatrutide: Lillys Triple-G Obesity Drug Moves Closer to Approval 21/5/26 Eli Lilly has reported major Phase 3 obesity-trial results for retatrutide, an investigational once-weekly injectable drug acting on GIP, GLP-1 and glucagon receptors

Together, these effects can reduce overeating and make it easier to maintain a calorie deficit, which is why GLP-1 for weight loss has become a major focus in obesity research

Moreover, in DNA methylation alterations of tumor cells induced by GLP-1RAs, studies have demonstrated that during breast cancer progression, tumor suppressor genes such as ESR1, CDH1, and ADAM33 are downregulated due to hypermethylation alterations in their promoter regions

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