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Specifically, expression of the kidney injury molecule-1 (KIM-1) was quantified, and it was found that patients who died from APAP-associated acute liver failure or who required liver transplant had significantly higher KIM-1 values on day 1 of presentation, as compared to those who spontaneously survived.69 Elevations of a kidney injury marker should not come as a surprise, however, as acute kidney injury evaluation in the form of serum creatinine is included in scoring systems such as the APACHE II and KCH criteria

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Acknowledgements We thank Pierre-Georges Meister for the conditioning of the medication and Philippe Maeder for his helpful comments throughout this study