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A 2024 randomized controlled study published in the Jurnal Kebidanan dan Keperawatan Aisyiyah specifically tested moringa leaf extract supplementation on GLP-1 levels in prediabetic models and found a clear dose-dependent effect: the higher the moringa dose, the higher the GLP-1 levels produced
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Interestingly, patients receiving tirzepatide report reduced overall GI AEs (40%), nausea (17.4%), diarrhea (13.2%) and vomiting (5.7%) compared to patients on semaglutide (43%, 19.2%, 13.7%, and 8.1% respectively)
In the CNS, GLP-1Rs are expressed by neurons in the hippocampus, which is known to be a cognition-related brain region, and have been observed in neocortical pyramidal neurons (Hamilton and Holscher, 2009)
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