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The trial randomised 2,339 adults with obesity (or overweight with a weight-related comorbidity) and without type 2 diabetes to retatrutide 4mg, 9mg, or 12mg weekly (titrated upward from 2mg in four-weekly steps) or placebo

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Omega-3 fatty acids: 1,000-2,000 mg EPA/DHA daily for cardiovascular and anti-inflammatory support

Exenatide administered once weekly as opposed to twice daily was found to lower HbA1c more significantly in the DURATION- 1 and DURATION- 5 trials ( 1.9% vs