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Even though there are concerns for the development of kidney disease in CPTII patients due to the high metabolic overload associated to rhabdomyolysis, end-stage chronic renal insufficiency requiring dialysis is only occasionally reported in these patients (Joshi and Zierz, 2020)

Consistently, overexpression of hHPN WT in hepsin / mice resulted in a significant increase in APAP tolerance, with survival rates exceeding 80% even after 80 h (Fig

Missing data was replaced by the mean when possible (see supplemental Table S11) eGFR was calculated using MDRD formula without race consideration: GFR, in mL/min per 1.73 m 2 = 175 SCr (exp[1.154]) Age (exp[0.203]) (0.742 if female)