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If you are using a microdosing protocol with more frequent injections, the same 72-hour minimum rule applies between each dose

Once the treatment is stopped, the effects are reversed fairly quickly

In some embodiments, the MDT for poloxamer from a formulation or device described herein is at least 6 hours

In the citric acid cycle, increased fumarate and succinate levels enhance malic enzyme activity and increase the conversion of pyruvate to malate [82], which in turn inhibits the conversion of pyruvate to oxaloacetate when there is an accumulation of acetyl CoA, further increasing the accumulation of malic acid [83]