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Although the efficacy of opto-genetic stimulation of the 5-HT neuron terminals and 5-HT receptor subtype-positive neurons in the PFC are needed as future experiments, these data suggest that pharmacological and opto-genetic activation of serotonergic neurons attenuates social and cognitive deficits and hyper-glutamatergic signaling in the PFC of prenatal VPA mice via 5-HT 1A receptors but fails to attenuate repetitive behavior by simultaneous activation of 5-HT 1A receptors

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