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Data from a randomized, double-blind, crossover study suggest that receipt of tramadol 2 mg/kg orally produces a greater analgesic effect, especially after the first 4 hours after dosing in extensive metabolizers whereas the analgesic effect in poor metabolizers is more modest but is sustained up to 10 hours after dosing
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The decision to continue, adjust, or discontinue treatment should always be made collaboratively, weighing the benefits of glycaemic control or weight management against any side effects experienced
Theardy, MS, Takeda, M, Sorokin, A, Chen, S, Yang, Z, Wang, X, Kanikarla, PM, Coker, O, Nguyen, P, Wei, Y, Yao, J, Yan, L, Jin, Y, Cai, Y, Paku, M, Chen, Z, Li, KZ, Citron, F, Tomihara, H, Gao, S, Deem, AK, Zhao, J, Wang, H, Hanash, S, DePinho, RA, Maitra, A, Draetta, G, Ying, H, Kopetz, S , Yao, W
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