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According to the FDA-approved prescribing information, patients start at 0.25 mg once weekly for the first four weeks (a dose-initiation phase not intended for blood sugar control), then increase to therapeutic doses

TGF- signaling is a key driver of this metabolic shift, upregulating enzymes such as PHGDH, PSAT1, PSPH, and SHMT1/2 that are essential for serineglycine biosynthesis and collagen production [17, 18]

The inflammatory response can activate the UPR through three major signaling pathways (PERK, ATF-6 and IRE1)

To optimize its effectiveness, you should make dietary and lifestyle changes while using the medicationand find a regular time to take it that fits into your schedule