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Melanocortin receptors are under circadian control, governed by the same hypothalamic clock genes (BMAL1, CLOCK, PER1/2) that regulate cortisol, melatonin, and body temperature
When people with a history of GORD were excluded, the association between GLP-1 RAs versus other second-line drugs and increased risk of new chronic cough was even stronger (adjusted hazard ratio 1.29)
The transition from semaglutide to tirzepatide is well documented
