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They were absolutely three alarming complications, but then we have enough evidence on all three to believe that we really do not have increased risk of any of them. However, one organ that has been affected by GLP-1 agonists in randomized trials is the gallbladder (7)

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However, its relatively short plasma half-life of 23 min, due to rapid degradation by dipeptidyl peptidase-4 (DPP-4), has prompted structural modifications to enhance its pharmacological efficacy