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Dysregulated GLP-1 signaling is centrally implicated in type 2 diabetes mellitus (T2D) and obesity, and GLP-1based therapies have shown benefit in reducing hyperglycemia, body weight, and some cardiovascular risk markers

Briefly, for each prediction the SHAP value of a particular variable is the difference in the model output when this variable is included versus when excluded

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The datasets had already been robust multi-array average-normalized in batches using the makecdfenv, affy and limma R packages, and batch-corrected using the ComBat method in the sva R package