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Pycnogenol s effects on endothelial function ( 2.7 Womens health Investigating the efficacy of Pycnogenol on the health of women, two RDP studies on menopausal symptoms ( An RDP study with 155 peri-menopausal women found the menopause symptoms assessed by the Womens Health Questionnaire (WHQ) to be significantly improved after six month of Pycnogenol supplementation, as compared to placebo controls ( supplemented subjects were significantly improved compared to enrollment and most items significantly compared to placebo