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Recently, Zynteglo (betibeglogene autotemcel), a gene therapy for -thalassemia, received conditional market approval in Europe [111,112]

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For example, a meta-analysis revealed the following changes when comparing GLP-1 agonists to placebo: Waist circumference dropped by 5.16 cm BMI decreased by 2.42 kg/m Triglycerides were reduced by 0.20 mmol/L Total testosterone levels fell by 1.33 ng/mL The reduction in waist circumference is particularly impactful because visceral fat is metabolically active and worsens insulin resistance

"Association between different GLP-1 receptor agonists and gastrointestinal adverse reactions: A real-world disproportionality study based on FDA adverse event reporting system database." Frontiers in Endocrinology