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DECLARED Decipher the GLP-1-Estradiol crosstalk to tackle postmenopausal Diabetes (DECLARED) The menopause-related decline in estradiol exposure interferes with glucose and energy homeostasis, translating into a 20 - 30% increased risk of type 2 diabetes, independent of the effect of ageing

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Ablation of Sim1 neurons causes obesity through hyperphagia and reduced energy expenditure

Additional mechanistic studies and in vivo validation are warranted to elucidate the molecular pathways and translational potential of this nanoformulated therapy