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And, in my view, it has to do with the GI tolerance at initiation and over the long term in chronic use, the convenience (injection and titration period of 16 weeks), and the need for lifestyle changes to show meaningful and sustained weight loss

By targeting three distinct incretin and metabolic pathways simultaneously, this compound allows researchers to observe unprecedented efficacy in weight regulation, metabolic homeostasis, and glycemic control compared to older single- or dual-agonist models

And then of course many others, perhaps some majority have some or even very significant spikes

Cost has already pushed many users to the brink, with 58% saying they've stopped or seriously considered stopping medication because of it