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This shift represents a move toward treatments that work with the body rather than against it

[1] Renal manifestations Mild polyuria Macroscopic hematuria Flank and/or abdominal pain Recurrent UTIs Nephrolithiasis Signs of CKD (e.g., fluid overload, uremia) Palpable, enlarged kidneys (usually normal at birth) Extrarenal manifestations Digestive Hepatic cysts: multiple, benign, mostly asymptomatic, and more prevalent with age Pancreatic cysts Colonic diverticulosis Abdominal or inguinal hernias Cardiovascular Symptoms of hypertension

These kinds of mechanisms have been defined for other drugs of abuse, such as morphine, and may be contributing in parallel to altered cocaine reward